This manga deals with an unusual topic: Inter Sexuallity. Aiesu (pronounced ai esu) means IS or Inter Sexuallity. If you have serious problems dealing with this topic, please do not read it. In my book, this is an 11 out of 10; 6 stars out of 5; Rank S! Taken from cases in the real world, it deals with IS in a very thoughtful fashion telling of the trials, tribulations and heartbreaks that being born and living life as an IS are like. It is a great read and I hope you think so as well.