FULL DISCLOSURE: I have not read the manga/light novel. STORY: Poyopoyo is a seinen 4-koma short anime about a family and their spherical cat. The major focus is on daily life issues and occurences with pets – mostly cats, and how they bring people together. There is somewhat of a continuous story as the events are portrayed in order over the course of a year or so. But being a 4-koma, most skits are able to stand on their own. The transitions between each one is quick and well-done. Each skit has either a somewhat informational or comedic purpose. ART+ANIMATION+SOUND: The art is a very basic scratchy stylethat is neither bad nor anything special. The animation is similarly basic, but it has the occasional impactful moments to fit with the humor.
The intro song is cute and catchy. The in-show music is pretty basic but matches the light nature of the show. Sound effects are basic.

CHARACTERS:
Poyo is the titular cat whose life the show primarily revolves around. He is spherical in shape and is therefore constantly mistaken as various different things.
Poyo’s owner and main caretaker, Moe (haha) is a 22-year old girl who lives in the country with her student brother, Hide, and bad-ass, farmer father, Shigeru. Moe is generally obsessed with Poyo and anything that remotely looks like him. While her father likes Poyo – with somewhat of a façade, Hide and Poyo do not get along very well, especially at first.
There are other animals and neighbors that appear constantly in the show, a few which have their running gags, but there is a surprising versatility among the characters. They bring plenty of possibilities to the anime.
Voice acting and character design are pretty basic, but the ‘voice’ of Poyo is Ootani Ikue of Pikachu/Chopper/etc. fame. There are a few other big-ish names in the cast as well.

ENJOYMENT:
This anime is very enjoyable for its cute moments, as well as the somewhat more mature themes and impactful humor. There are a few references thrown in as well.
Including characters of many different ages gives the show an interesting dynamic, along with the various pet owners and their personalities.

OVERALL: Silly and cute 4-koma about pets for more mature audiences, great to binge or to watch in chunks.