The story line is simply sublime although I would of expected Misaki Suzuhara to be more annoyed with her mum at the end but this would have been an expected reaction. I like the idea of using medical research to create a game to gains fund and improve the technology this story line alone makes this worth it. However at the end I wanted to know did Misaki mother diced to marry Ichiro? I don't think any good Anime collection should be without this show, maybe I just like the stuff the guys & girls at Bones put out. If you have not seen thisshow watch it you might love it, I wise there were more Anime's of this standard out there.